Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot studySARS-COV-2 감염 및 급성 신장 손상 마커에 의해 유도 된 변경된 신장 기능 COVID-19 환자의 생존 결과를 예측합니다 : 전향 적 파일럿 연구Article Published on 2022-12-012022-08-31 Journal: Renal failure [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute kidney Acute kidney injury adjusted Advancing age Altered Analysis association Biomarker chronic Chronic kidney disease collaboration Comorbidities Comorbidity Control coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 COVID-19 patient COVID-19 patients creatinine Cumulative rates cystatin C death demonstrated elevated examined group groups Hospitalized ICU intensive care intensive care unit investigated Kaplan-Meier method kidney kidney damage Kidney disease Kidney function Kidney function tests Kidney injury literature marker morbidity multivariable Cox regression outcome participant pilot study predict Predictive Predictive value Proteinuria retained risk factor Risk factors SARS-COV-2 infection serum serum creatinine Sex significant difference statistically subject survival survival analysis survival analysis. the Kaplan-Meier method Treatment Urine with COVID-19 [DOI] 10.1080/0886022X.2022.2032743 PMC 바로가기 [Article Type] Article
The vulnerability of maintenance dialysis patients with COVID-19: mortality and risk factors from a developing countryObservational Study Published on 2022-12-012022-10-04 Journal: Annals of Medicine [Category] 임상, [키워드] age Blood Group Characteristics Clinical features collected data complications country COVID-19 death demographics diabetes dialysis epidemiological Factor General population Haemodialysis hospitalisation ICU admission implementation incidence incidence of COVID-19 increased risk independent risk factor infected patient Infection infection control intensive care intubation Male sex measure Measures Mortality mortality rate mortality rate; multivariable logistic regression old age outcomes Patient patients Peritoneal dialysis peritoneal dialysis. positive Predictive reduce required retrospective risk risk factor risk of infection significantly significantly increased smoking study period tested therapy Vascular venous catheter was used West Bank [DOI] 10.1080/07853890.2022.2075914 PMC 바로가기 [Article Type] Observational Study
Evaluating correlates of protection for mix-match vaccine against COVID-19 VOCs with potential of evading immunityArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] appear Bayesian Beta ChAdOx1 Clinical efficacy Correlate of protection COVID-19 D614G Delta Delta VOC distribution Efficacy ENhance evaluate Evaluating finding Heterologous highlight homologous Immunity inversion Mix-match mRNA-1273 neutralizing antibody omicron pandemic phase 3 trial predicted Predictive previous study provide ranged reduction reductions in strain vaccination Vaccine variant Variant of concern. variants variants of concern VoC VOCs was used while Wuhan [DOI] 10.1016/j.vaccine.2022.10.011 PMC 바로가기
Enhanced Label-Free Nanoplasmonic Cytokine Detection in SARS-CoV-2 Induced Inflammation Using Rationally Designed Peptide AptamerArticle Published on 2022-11-022022-11-15 Journal: ACS applied materials & interfaces [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome Analysis Antibody-derived peptide aptamer (ADPA) applied aptamer Biomarker coronavirus COVID-19 patients cytokine detection Detection limit Disease progression disorders enhanced IL-6 immune pathway Immune status immunoassay immunoassays in vitro induced Inflammation inflammatory status information interleukin 6 (IL-6 Interluekin-6 (IL-6) Interpretation limit of detection localized surface plasmon resonance (LSPR) magnitude nanoplasmonic immunoassay pandemic pathogenic inflammation Patient peptide Predictive profile Prognosis provide quantification Rapid SARS-CoV-2 serum serum cytokine Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [DOI] 10.1021/acsami.2c14748 PMC 바로가기
Evaluation of Procalcitonin’s Utility to Predict Concomitant Bacterial Pneumonia in Critically Ill COVID-19 PatientsArticle Published on 2022-11-012022-11-15 Journal: Journal of Intensive Care Medicine [Category] 바이오마커, [키워드] Antibiotic therapy AUC Bacteremia Bacterial Bacterial infection bacterial pneumonia baseline characteristics Concomitant conducted COVID-19 creatinine Critical Critical illness Critically ill patient Culture defined determine diagnosing diagnostic ENhance evaluate group hospitalized patients ICU ICU patient identify Ill in-hospital mortality intensive care intensive care unit Mortality multivariable multivariable model no difference no significant difference offer outcome Patient PCT Pneumonia positive predict Predictive procalcitonin procalcitonin. receiver operating characteristics Regression model retrospective cohort study ROC SARS-CoV-2 secondary bacterial pneumonia serum creatinine Severe COVID-19 pneumonia Severity of disease specificity threshold utility variable vital signs was used while with COVID-19 [DOI] 10.1177/08850666221108636 PMC 바로가기
Exploring the anti-SARS-CoV-2 main protease potential of FDA approved marine drugs using integrated machine learning templates as predictive toolsArticle Published on 2022-11-012022-11-15 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] activity Activity atlas model Activity cliff Algorithm anti-SARS-CoV-2 approved Atla Biological camostat Compound COVID-19 COVID-19 pandemic Cresset data set docked drug drugs effective FDA field Field template FIVE flare group Holichondrin B inactive macromolecules Marine drugs. nafamostat outbreak Predictive protease Protein remained Repurposed drug responsible Safe SARS-CoV-2 Structure structures [DOI] 10.1016/j.ijbiomac.2022.09.086 PMC 바로가기
Serological biomarkers of COVID-19 severity at hospital admission are not related to long-term post-COVID pain symptoms in hospitalized COVID-19 survivorsArticle Published on 2022-11-012022-11-15 Journal: Pain [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Analysis analyzed association Biomarker Clinical data cohort study collected collecting data Comorbidities conducted coronavirus disease COVID-19 COVID-19 severity discharge exhibited Factors First wave Glucose greater hospital Hospital admission hospital discharge hospitalised Hospitalized hospitalized COVID-19 Inflammatory biomarker investigated Lymphocyte count Other outbreak Pain participant Patient Predictive Prevalence serological severity significantly Spain survivor Survivors Symptom Symptoms were assessed with COVID-19 women [DOI] 10.1097/j.pain.0000000000002608 PMC 바로가기
An explainable model of host genetic interactions linked to COVID-19 severityArticle Published on 2022-10-262022-11-16 Journal: Communications Biology [Category] 변종, 유전자 메커니즘, [키워드] age and gender Analysis classifiers Cohort contributing to covariates COVID-19 COVID-19 severity dataset Factor Features Follow-up Genetic GWAS high accuracy highest Host identify immune pathways immune system increased risk Inflammatory Interaction Italian patients MCC molecular mechanism offer outcome Patient phenotypic predict predicted Predictive screened several variant Severe COVID-19 Infection severity Signaling significantly Stratification stratified Support tested therapeutic intervention Thoracic variant viral infection WES with COVID-19 [DOI] 10.1038/s42003-022-04073-6 PMC 바로가기
Diagnostic performance of corona virus disease 2019 chest computer tomography image recognition based on deep learning: Systematic review and meta-analysisArticle Published on 2022-10-212022-11-15 Journal: Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy article articles assist AUROC authors characteristic Chest chest computer tomography China Cochrane Library combating country COVID-19 COVID-19 pandemic COVID-19 patient deep learning defined demographics Diagnosis diagnostic Final healthy highest inception inclusion criteria individual Infrastructure likelihood ratio Meta-analysis non-infected Odds ratio outcome Patient patients Pneumonia positive Predictive produced radiologist Research researcher resolved ROC Sample size screened searched secondary sensitivity Sensitivity and specificity specificity subgroup suspected patient Symptoms Virus Disease Web of Science [DOI] 10.1097/MD.0000000000031346 PMC 바로가기
Could an Increased Percentage of Immature Granulocytes Accompanying Dyspepsia Predict COVID-19?Article Published on 2022-10-152022-11-15 Journal: Medicina [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accompanying acute respiratory syndrome C-reactive protein coronavirus COVID-19 COVID-19 infection COVID-19 symptom CRP cut-off value determine digestive digestive symptom dyspepsia early diagnosis granulocyte immature immature granulocyte. Increased Material and Method Neutrophil-to-lymphocyte ratio NLR novel coronavirus disease parameter Patient patients pediatric Pediatric patient percentage polymerase chain positive Predictive SARS-CoV-2 SARS-CoV-2-positive patient significantly higher tested two groups typical symptom vaccination was determined were recorded [DOI] 10.3390/medicina58101460 PMC 바로가기